BIOSTABLE Science & Engineering

Simplifying and Standardizing Aortic Valve Repair

BioStable Science & Engineering is a cardiovascular device company focused on developing and commercializing proprietary valve repair technologies that provide an alternative to valve replacement for patients with aortic valve disease.

Read more about our company, management and mission.

BioStable products

Aortic Valve Disease

“Aortic valve insufficiency is the most common valvular heart disease, affecting more than 2.5 million adults world-wide.”[Read more]

Valve Repair vs Replacement

“Valve repair is more durable than biological valve replacement and avoids the complications associated with anticoagulation medications required with mechanical valve replacement.”[Read more]

HAART Aortic Valve Repair Technologies

Resize the aortic valve annulus to reduce dilatation,
Reshape the aortic valve to restore more normal, three-dimensional coaptation geometry,
Stabilize the aortic valve to reduce the risk of recurrent annular dilatation.

HAART 300 Aortic Annuloplasty Device

HAART 300 Aortic Annuloplasty Device

The HAART 300 Aortic Annuloplasty Device was designed from mathematical reconstructions of high resolution, computed tomographic angiogram (CTA) images of normal aortic valves.

HAART 200 Aortic Annuloplasty Device

The HAART 200 Aortic Annuloplasty Device has been designed specifically for use during the repair of bicuspid aortic valves.

(The HAART 200 Aortic Annuloplasty Device is not available for sale outside of the U.S.)

Standard Annuloplasty Technique

Correct device sizing is determined from leaflet free-edge lengths to restore appropriate annular dimensions and commissure positioning for the patient’s individual leaflet anatomy.

Aortic Root Restoration

Valve Sparing Root Replacement Simplified

Aortic root remodeling plus annuloplasty with the HAART Aortic Annuloplasty Device simplifies valve repair and eliminates root dissection.

News and Events

Resource — Aortic valve repair for tri-leaflet aortic insufficiency associated with asymmetric aortic root aneurysms – Article from Annals of Cardiothoracic Surgery … Stavridis GT, Downey RS, Gerdisch MW, Hughes GC, Jasinski MJ, Rankin JS, Mazzitelli D, Aicher D, Fischlein T, Choi YH, Weber A, Friedrich I, Glauber M, Pfeiffer S, Miceli A, Si MS, Klokocovnik T, Wei LM, Deja MA, Badhwar V. Aortic valve repair for tri-leaflet aortic insufficiency associated with asymmetric aortic root aneurysms. Ann Cardiothorac Surg 2019;8(3):426-429. doi: 10.21037/acs.2019.04.10 … [Read more]

Article — Apr 12, 2019 (article from the Daily Journal) Heart valve surgeon providing patients with innovative options – Article by Ryan Trares, reporter for the Daily Journal. … Pagano was the patient of Dr. Marc Gerdisch, chief of cardiovascular and thoracic surgery and co-director of the Heart Valve Center at Franciscan Health Indianapolis. Through Gerdisch’s leadership, the heart center has become one of the most innovative in the world, proving to be on the forefront of new ways to repair damaged heart valves to ensure patients have longer and healthier lives … [Read more]

Article — Apr 3, 2019 (article from Breakthrough Innovation: The HAART Aortic Annuloplasty Device Cleared by the FDA – Article by Adam Pick, founder of … The HAART Aortic Annuloplasty Device received clearance from the U.S. Food & Drug Administration (FDA). This is a very important development for patients who are searching for a potential long-term fix for their leaking aortic valves. The great news is that the early operative results using the HAART device have supported a global trend toward aortic valve repair … [Read more]

Video — Columbia, SC – March, 2019 (video from WIS-TV) A New Tool to Treat Aortic Valve Disease is a ‘Game Changer’First surgery in South Carolina to use FDA approved HAART 300 Aortic Annuloplasty Device … A Midlands man undergoes aortic valve repair utilizing a new surgical option, the HAART 300. Dr. Ryan Burke is the first physician in South Carolina to utilize this new technology that simplifies and standardizes the aortic valve repair operation. [Read more]

Article — Feb 11, 2019 (article from CardioVascular News Issue 52 – Feb 2019) Early results for HAART 200 and HAART 300 Aortic Annuloplasty Devices are encouraging – The Duke Children’s Pediatric & Congenital Heart Center (Duke University Medical Center, Durham, USA) treats the entire spectrum of patients with complex congenital heart disease. In this article, Cardiovascular News focuses on how the centre manages patients with congenital aortic valve disease—specifically, their use of the HAART 200 and HAART 300 (both BioStable) internal aortic valve annuloplasty rings.” … [Read more]

Video — San Antonio, TX – July 12, 2018 (video from KENS-TV) Brand new heart surgery saves San Antonio teen’s lifeFirst surgery in Texas to receive FDA approved HAART 300 Aortic Annuloplasty Device … A 15-year-old San Antonio boy who has a heart defect is getting a second chance at life thanks to a brand new procedure he was the first to receive. [Read more]

Article — Chicago, IL – March 29, 2018 (article from Northwestern Medicine) Northwestern Memorial Hospital Surgeon First in Illinois to Repair Aortic Valve with Novel RingHAART 300 Aortic Annuloplasty Device Duplicates the Heart’s Anatomy … “Repairing a valve is always better than replacing a valve, and until now we have never had an aortic annuloplasty device for repair,” said Dr. Malaisrie, who is also an associate professor of surgery – cardiac surgery at Northwestern University Feinberg School of Medicine. “There’s a bright future for aortic valve repair, and this device provides another opportunity for us to do so with better and longer-lasting repairs.” … [Read more]

[Read more News articles]

Press Release — Austin, TX – Feb 25, 2020 — BioStable Science & Engineering Announces Initial Closing of Series C Equity Round

Lead investors Rex Health Ventures and Orlando Health Ventures were joined by Longmeadow Health Care Partners, Santé Health Ventures, Solas BioVentures, and other prior investors … [Read more]

Press Release — Austin, TX – May 3, 2019 — BioStable Science & Engineering Surpasses 500 Patients Treated Worldwide with the HAART Devices

BioStable Science & Engineering, a medical technology company focused on products for aortic valve repair for the treatment of aortic insufficiency, today announced that over 500 patients worldwide … [Read more]

Press Release — Austin, TX – Sept 26, 2017 — BioStable Science & Engineering announces the First Commercial Use of the HAART 200 Aortic Annuloplasty Device

The first commercial use of the HAART 200 Aortic Annuloplasty Device in the U.S. by doctors at the West Virginia University (WVU) Heart and Vascular Institute in Morgantown, West Virginia … [Read more]