Aortic valve repair for tri-leaflet aortic insufficiency associated with asymmetric aortic root aneurysms

Article from Annals of Cardiothoracic Surgery (Submitted Jan 26, 2019. Accepted for publication Apr 24, 2019.)

Stavridis GT, Downey RS, Gerdisch MW, Hughes GC, Jasinski MJ, Rankin JS, Mazzitelli D, Aicher D, Fischlein T, Choi YH, Weber A, Friedrich I, Glauber M, Pfeiffer S, Miceli A, Si MS, Klokocovnik T, Wei LM, Deja MA, Badhwar V. Aortic valve repair for tri-leaflet aortic insufficiency associated with asymmetric aortic root aneurysms. Ann Cardiothorac Surg 2019;8(3):426-429. doi: 10.21037/acs.2019.04.10

The patient was a 47-year-old male with mild heart failure and an expanding 5.2-cm ascending aortic aneurysm. His sinuses also were involved, with a 6.3-cm aortic root diameter. He had Grade 4 aortic insufficiency (AI) (Figure 1) and his left ventricle and coronaries were normal. His aortic annulus was especially dilated at 30 mm. The right and non-coronary sinuses were primarily involved in the root aneurysm and his left sinus seemed normal. Echocardiography showed the dilated annulus, leaflet tethering from the sinotubular junction (STJ) dilatation and normal appearing leaflets. The AI was central and severe with stretching of the leaflets and loss of central coaptation. No leaflet prolapses or other defects were evident.

Figure 1: Echocardiographic and video images of the aortic valve, before and after the repair.

Preparation-exposition
In this patient, we chose to (I) repair the aortic valve and (II) to selectively replace only the aneurysmal right and non-coronary sinuses. Midline sternotomy was employed and conventional cardiopulmonary bypass via the distal ascending aorta and the right atrium was utilized, with anterograde and retrograde Custodiol™ cardioplegia. Initially, we applied retrograde cardioplegia to arrest the heart followed by direct administration into both coronary ostia.

Operation
The aorta was opened high, to avoid possibly displaced coronary ostia, and a circular aortotomy was completed down to within 1 cm of the coronaries and commissural tops. The ascending aneurysm was excised and again, the right and non-coronary sinuses appeared aneurysmal, with a normal left sinus and nice leaflets. Traction sutures were placed horizontally above each commissural top, and the annulus sized to 30 mm (video: http://www.jsrmd.com/ftp/245_ARAc.mp4). The commissure-to-commissure free-edge length of the left coronary leaflet suggested a 23-mm ring, as did the non-coronary; however, the right leaflet was 25. Therefore, the ring was downsized to 23, with the minor axis left/non-coronary post facing posteriorly.

Aortic valve repair
Positioning the ring posts low into the subcommissural triangles raises the tops of the commissures relative to the valve base and increases vertical leaflet coaptation height. To accomplish this goal, each subcommissural triangle was marked with a blue dot, 3 mm below the top of the subcommissural space (video: http://www.jsrmd.com/ftp/245_ARAc.mp4). During subsequent ring placement, all commissural annular sutures were kept at or below the blue dot. With the ring above the valve, each commissural post was sutured into the subcommissural triangle using Cabrol-like 4-0 Prolene horizontal mattress sutures. The ring was lowered below the valve, and two looping annular sutures were placed in each sinus—effectively looping the ring. For a #19 annuloplasty ring, only one looping suture per sinus would be required (6 total sutures). Small supra-annular Dacron pledgets were positioned on each suture.

After all annular sutures were placed, the three commissural sutures were tied tightly as a first step with eight good knots. Getting the sutures tied tightly is especially important. Then, one needle was passed downward and lateral through the pledget (away from the leaflet) and tied with 6–7 more knots. This “lateral suture fixation” has minimized technical complications, such as knot untying and leaflet contact with the suture tails. At the end, all suture knot towers faced laterally and the ring was buried into the annulus and could not be seen. Leaflet coaptation was tested by “pressurizing” all three leaflets simultaneously with closed DeBakey forceps and the leaflets were quite vertical, coapted well in the midline and had equivalent effective heights.

Aortic root replacement
Attention then was turned to the aorta. Normal segmental sinus circumference should be just a little larger than the leaflet free-edge length (1-3) and in this patient, the right sinus was almost twice that dimension (see video). The non-coronary sinus also was much larger, but the left sinus was normal. The non-coronary and right sinuses were excised and the right coronary button was developed. A 30-mm Valsalva graft (7 mm larger than the annuloplasty ring) was chosen and the bottom skirt removed. Three 120° tongues were developed and the right and non-coronary tongues were sutured to their respective sinuses. The tongue for the normal left sinus was removed and the proximal root anastomosis was carried across the top of the left sinus. The single right coronary ostium was implanted into the graft and the distal aortic anastomosis was completed.

Completion
Post-bypass, the leaflets exhibited excellent effective height and moved well with no residual leak (Figure 1). After valve repair, the mean valve gradient was 7 mmHg.

Clinical results
In the original clinical trials of aortic ring annuloplasty in aneurysm patients 7 years ago, outcomes were good (4), despite being very early in the technical learning curve. Shown in Figure 2, survival free of all complications was excellent, AI reduction was clinically and statistically significant, gradients were low and symptom reduction was good (4). Problems identified in the trials, such as annular suture untying and leaflet lacerations from long annular suture tails have been virtually eliminated in the subsequent 400 patients by lateral suture fixation. Thus, future clinical outcomes are likely to be even better.

Figure 2: Outcome data after aortic valve repair associated with aortic aneurysm surgery using geometric ring annuloplasty. Scrn, screening; Disch, discharge; mo, month; NYHA, New York Heart Association.

Advantages
Geometric ring annuloplasty is a simple and effective technique for aortic valve repair during aortic aneurysm surgery (4). Important technical points include: (I) downsizing ring size whenever a question exists, (II) positioning ring posts low in the subcommissural triangles and (III) applying “lateral suture fixation” to every annular suture. With aortic root involvement, selective replacement of only the abnormal sinuses simplifies the procedure, using a remodeling root graft (5).

Caveats
The most pathologic aortopathies, such as Ehlers-Danlos syndrome and Loeys-Dietz syndrome, might be excepted from this approach, and certainly, clinical judgment should be operative in all cases. Finally, more long-term follow-up data will be required for better understanding of this subject.

Funding: The research was supported by BioStable Science and Engineering (BSE), Austin Texas, USA (www.biostable-s-e.com).

1. Conflicts of Interest: Drs. JS Rankin, MW Gerdisch, MJ Jasinski, D Mazzitelli, YH Choi, T Fischlein, A Weber, M Glauber, MS Si, GT Stavridis, and LM Wei are consultants for BSE. The other authors have no conflicts of interest to declare.

1. Rankin JS, Bone MC, Fries PM, et al. A refined hemispheric model of normal human aortic valve and root geometry. J Thorac Cardiovasc Surg 2013;146:103-8.e1.
2. Crooke PS, Beavan LA, Griffin CD, et al. Design characteristics of a three-dimensional geometric aortic valve annuloplasty ring. Innovations (Phila) 2013;8:364-70.
3. Crooke PS, Beavan LA, Griffin CD, et al. A geometric model of the normal human aortic root and design of a fully anatomic aortic root graft. Innovations (Phila) 2015;10:57-62.
4. Rankin JS, Mazzitelli D, Fischlein T, et al. Geometric Ring Annuloplasty for Aortic Valve Repair During Aortic Aneurysm Surgery: Two-Year Clinical Trial Results. Innovations (Phila) 2018;13:248-53.
5. Urbanski PP, Jankulowski A, Morka A, et al. Patient-tailored aortic root repair in adult marfanoid patients: Surgical considerations and outcomes. J Thorac Cardiovasc Surg 2018;155:43-51.e1.

Read the entire article on the Annals of Cardiothoracic Surgery website.

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